Tag Archives: genetics

Five lessons I’ve learned about genetics

I admit that I began reading to find evidence that supported my view. I was sure science would back me up. And then I, complete with a list of Harvard-format references, would win the next debate. The problem was that science didn’t agree with me. I could find pockets of supporting evidence, but the overwhelming consensus was that I was wrong. It made me phenomenally uncomfortable to see a consensus emerging that directly contradicted my beliefs about how the world should be. But ultimately, science is not about how the world should be. Science is about how the world is. And if I want to make it different, I need an accurate picture of how it is now.

This is a blog on reading about genetics – what I’ve learned, and what I want to do about it. The lessons are the things that struck me as a teacher most, and are largely based on reading about intelligence or other cognitive characteristics. I want to note up front that I am not an expert, and that writing this is part of my attempt to learn more. If and when I’ve made a mistake please let me know and I will rectify it as quickly as possible.

Lesson #1: Genetics explains much more of the variation between people than I was willing to accept
The most influential type of study for this blog is the twin study, which looks to explain the variation between people and attribute it to one of three categories of cause: the shared environment (factors that would be common to a pair of twins living in the same household and attending the same school); the non-shared environment (all other environmental factors); and genetics. Studies of cognitive ability tend to find that variation is 10-20% shared environment, 30-40% non-shared environment, and 50-60% genetics.

This was hard for me to accept. I wanted to believe that most variation is caused by things within our control. Instead the shared environment, of which school is only one part, explains under a fifth of the variation between people.

Before moving on to Lesson #2 it is important to stress that we are talking about variation here – not absolute levels. We can say that 50% of variation in intelligence is genetic in origin, we can say nothing about how much of your intelligence is caused by your genes.

Lesson #2: Environments change how genes are expressed
Your genetic code is fixed, but what you do with it isn’t. Geneticist Nessa Carey likens your genetic code to the script of a play, which is then interpreted extensively by the actors and director before becoming the performance that eventually appears on stage. Epigenetics is the study of these interpretations, which are as crucial to our biological functioning as the genetic code itself.

One thing we learn from epigenetics is that our environment shapes how we interpret our genetic code, and that these interpretations stick. Once we have scrawled annotations over our genetic script they will stay unless we actively rub them out – and when our children inherit our scripts they will find many of our annotations still in place.

Extreme or consistent environmental stimuli can create epigenetic modifications that change how your genes are expressed. For example, a stressful environment can lead to genes that control the production of cortisol (a stress hormone) becoming over-expressed, meaning that you become much more easily stressed in the future. Such a change will then persist, shutting off chunks of working memory and reducing executive function in years to come.

As many epigenetic modifications are heritable it is difficult for twin studies to separate their effect from the effect of genes themselves, and so it is possible that some of the causal impact of genetics is actually environmental in origin. As our ability to do more complex analysis with the genome itself increases we will no doubt find out whether this possibility means anything in practice.

Lesson #3: Environments correlate with genes
A tall child is more likely than a short child to be asked to try out for the basketball team. Where we may have a genetic propensity towards a certain area we tend to seek out (or be pushed towards) an environment that increases that propensity. This means that a small effect that begins life as just an inkling of interest or talent can easily grow into a specialised environment that exaggerates initially small effects. It is possible that correlations like this are responsible for a significant proportion of our genes’ impact. If we adapt environments, whether consciously or not, we will be magnifying genetic differences.

Lesson #4: Genetics does not determine outcomes
Twin studies observe the differences we see today and explain their origins. They do not have any say in how big these differences are or will be in the future. So the fact that 50% of variation in a characteristic is due to genetic causes today does not mean that it must be tomorrow. Nor does it mean that we must accept present levels of difference as necessary. The numbers we find in these studies are not natural constants.

Behavioural geneticist Robert Plomin says that studies tell you what is, not what could be. He likens our genetic understanding of intelligence to our understanding of weight. Whilst it is obviously the case that people can be genetically predisposed to put on more or less weight than each other, it is also true that with the right interventions almost anybody can achieve a healthy weight. The same is true for intelligence. There may be genetic predispositions, but we can make sure that everybody achieves an acceptable level by providing the right environment.

Lesson #5: Genetics assumes determinism
If a study assumes that all difference is caused by either genetics, the shared environment or the non-shared environment, then it is also making one other underlying assumption: that everything about a person has an external cause. It assumes that your intelligence or success is a function solely of your genes and your environment. But what if everything about us is not 100% deterministic?

I was hesitant to write this lesson down, for fear of seeming to criticise the entire body of work genetics has given us. Science has to operate by studying the relationship between cause and effect. I cannot challenge it for failing to account for independent free will. But I am nonetheless uncomfortable not accounting for it. I do not know nearly enough in this area to do anything more than speculate. But I do wonder whether the large influence of the non-shared environment, that bucket for everything we can’t put our finger on, may be substantially down to things like attitude and motivation that may not be fully caused by an external mechanism.

So what do I take from all this?
Firstly, that genetics plays an unquestionably big role in explaining who we are, and how our brains work. Even if some of the effect attributed to genes is in fact environmental in origin (due to epigenetics or gene-environment correlations) there is no doubt that genes have a huge influence.

But secondly, even though genes make us all different, they don’t determine our cognitive future. Long-term memory still has unlimited capacity; brain plasticity is still immense; and good teaching can still take advantage of this. Genes determine difference, but they’re no excuse for educational inequality.